三只刺龙虾的热敏感性与细胞心脏衰退有关

Thermal sensitivity links to cellular cardiac decline in three spiny lobsters

Keywords：Animal metabolism, cardiac performance and mitochondrial function

关键词：动物代谢、心脏性能、线粒体功能
作者：Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G
出版期刊：《Scientific Reports》 2020/1/14

Abstract：

Understanding mechanisms of thermal sensitivity is key to predict responses of marine organisms to changing temperatures. Sustaining heart function is critical for complex organisms to oxygenate tissues, particularly under temperature stress. Yet, specific mechanisms that define thermal sensitivity of cardiac function remain unclear. Here we investigated whole animal metabolism, cardiac performance and mitochondrial function in response to elevated temperatures for temperate, subtropical and tropical spiny lobster species. While oxygen demands increased with rising temperatures, heart function became limited or declined in all three species of lobsters. The decline in cardiac performance coincided with decreases in mitochondrial efficiency through increasing mitochondrial proton leakage, which predicts impaired compensation of ATP production. Species differences were marked by shifts in mitochondrial function, with the least thermal scope apparent for tropical lobsters. We conclude that acute temperature stress of spiny lobsters, irrespective of their climatic origin, is marked by declining cellular energetic function of the heart, contributing to an increasing loss of whole animal performance. Better understanding of physiological thermal stress cascades will help to improve forecasts of how changing environmental temperatures affect the fitness of these ecologically and commercially important species.

文章摘要：

了解热敏感性机制是预测海洋生物对温度变化反应的关键。维持心脏功能对于复杂生物为组织充氧至关重要，尤其是在温度压力下。然而，定义心脏功能热敏感性的具体机制仍不清楚。在这里，我们研究了温带、亚热带和热带刺龙虾物种在温度升高时的整个动物代谢、心脏性能和线粒体功能。虽然氧气需求随着温度升高而增加，但所有三种龙虾的心脏功能都变得有限或下降。心脏功能的下降与通过增加线粒体质子泄漏而降低的线粒体效率同时发生，这预示着 ATP 产生的补偿受损。物种差异的特点是线粒体功能的变化，热带龙虾的热范围最小。我们得出结论，刺龙虾的急性温度应激，无论其气候来源如何，都以心脏细胞能量功能下降为特征，导致整个动物性能的损失越来越大。更好地了解生理热应力级联将有助于改进对环境温度变化如何影响这些生态和商业重要物种的适应性的预测。

点击链接即可查看和下载文章：https://www.nature.com/articles/s41598-019-56794-0

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